Early stage drug discovery faces many challenges. Therefore, experimental data has to be generated as efficiently and reliably as possible. Recent insights in the molecular pharmacology of the histamine H4 receptor has shown that significant species differences exist, causing H4R ligands to show distinct pharmacodynamic behavior. Between the species, a single H4R ligand can show the entire spectrum of functional activities ranging from inverse agonist to antagonist to agonist. Griffin Discoveries offers a unique histamine receptor profiling service that can accurately show your compounds’ behavior at the different histamine receptor subtypes (H1R-H4R) as well a many of the species orthologues including human, mouse, rat, monkey and dog receptors and several others. The histamine receptor profiling service allows for the reliable interpretation of the observed in vivo experimental data of H4R ligands.